References

1. Maetzel, A, Makela, M, Hawker, G, Bombardier, C. 1997. Osteoarthritis of the hip and knee and mechanical occupational exposure: a systematic overview of the evidence. J. Rheumatol. 24:599-607; Felson, DT, Lawrence, RC, Dieppte, PA, Hirsch, R, Helmick, CG, Jordan, JM, Kington, RS, Lane, NE, Nevitt, MC, Zhang, Y, Sowers, M, McAlindon, T, Spector, TD, Poole, AR, Yanovski, SZ, Ateshian, G, Sharma, L, Buckwalter, JA, Brandt, KD, Fries, JF. 2000a. Osteoarthritis: New Insights: Part 1: The Disease and Its Risk Factors. Ann Intern Med, 133(8): 635-646; Felson, DT, Lawrence, RC, Hochberg, MC, McAlindon, T, Dieppe, PA, Minor, MA, Blair, SN, Berman, BM, Fries, JF, Weinberger, M, Lorig, KR, Jacobs, JJ, Goldberg, V. 2000b. Osteoarthritis: New Insights. Part 2: Treatment Approaches. Ann Internal Med, 133(9):726-737; Deschner, J, Hofman, CR, Piesco, NP, Argarwal, S. 2003. Signal transduction by mechanical strain in chondrocytes Curr. Opin. Clin. Nutr. Metab. Care. 6: 289-93.
2. Felson, DT, Lawrence, RC, Dieppte, PA, Hirsch, R, Helmick, CG, Jordan, JM, Kington, RS, Lane, NE, Nevitt, MC, Zhang, Y, Sowers, M, McAlindon, T, Spector, TD, Poole, AR, Yanovski, SZ, Ateshian, G, Sharma, L, Buckwalter, JA, Brandt, KD, Fries, JF. 2000a. Osteoarthritis: New Insights: Part 1: The Disease and Its Risk Factors. Ann Intern Med, 133(8): 635-646.
3. Bunting, S, Moncada, S, Vane, JR. 1983. The prostacyclin—thromboxane A2 balance: pathophysiological and theraputic implications. Br. Med. Bull. 39:271-6.
4. Solomon DH. 2005. Selective cyclooxygenase 2 inhibitors and cardiovascular events. Arthritis Rheum. 52(7):1968-78; Bing, RJ, Lomnicka, M. 2002. Why do cyclo-oxygenase-2 inhibitors cause cardiovascular events? J. Am Coll Cardiol. 39:421.
5. Hudson, N, Balsitis, M, Everitt, S, Hawkey, CJ. 1993. Enhanced Gastric Mucosal Leukotriene B4 Synthesis in Patients Taking Non-steroidal Anti-Inflammatory Drugs. Gut, 34:742-7.
6. Felson, DT, Lawrence, RC, Dieppte, PA, Hirsch, R, Helmick, CG, Jordan, JM, Kington, RS, Lane, NE, Nevitt, MC, Zhang, Y, Sowers, M, McAlindon, T, Spector, TD, Poole, AR, Yanovski, SZ, Ateshian, G, Sharma, L, Buckwalter, JA, Brandt, KD, Fries, JF. 2000a. Osteoarthritis: New Insights: Part 1: The Disease and Its Risk Factors. Ann Intern Med, 133(8): 635-646.
7. Martel-Pelletier J, Mineau F, Fahmi H, Laufer S, Reboul P, Boileau C, Lavigne M, Pelletier JP. 2004. Regulation of the expression of 5-lipoxygenase-activating protein-5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids. Arthrits Rheum. 50(12):3925-33; Marcouiller P, Pelletier JP, Guevremont M, Martel-Pelletier J, Ranger P, Laufer S, Reboul P. 2005. Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membrane: regulating factors for interleukin 1beta synthesis. J. Rheumatol. 32(4):704-12.
8. Martel-Pelletier, J, Lajeunesse, D, Reboul, P, Pelletier, JP. 2003. Therapeutic Role of Dual Inhibitors of 5-LOX and COX, Selective and Non-Selective Non-Steroidal Anti-Inflammatory Drugs. Ann. Rhem. Dis, 62:501-09.
9. Goetzl EJ, An S, Smith WL. 1995. Specfficity of expression and effects of eicosanoid mediators m normal physiology and human diseases. FASEB J. 9:1051-1058; The Eicosanoids, Ed. Curtis-Prior P, John Wiley & Sons, New York, NY, 2004.
10. Bunting, S, Moncada, S, Vane, JR. 1983. The prostacyclin—thromboxane A2 balance: pathophysiological and theraputic implications. Br. Med. Bull. 39:271-6.
11. Poonam D, Vinay CS, Gautam P. 2005. Cyclo-oxygenase-2 expression and prostaglandin E(2) production in experimental chronic gastric ulcer healing. Eur J Pharmacol. Aug 30; Brzozowski T, Konturek PC, Konturek SJ, Sliwowski Z, Pajdo R, Drozdowicz D, Ptak A, Hahn EG. 2001. Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microsc Res Tech. 53(5):343-53.
12. Laufer S. 2001. Discovery and development of ML3000. Inflammopharmacology. 9(1-2):101-112.
13. Data on file.
14. Silva, S, Jia, Q, Mesches, M, and Burnett, BP. 2005. Safety Evaluation of a Naturally Derived, Dual Cyclooxygenase and Lipoxygenase Inhibitor. Under review, J. Food Chem. Toxicol.
15. Elliott GA, Purmalis A, VanderMeer DA, Denlinger RH. 1988. The propionic acids. Gastrointestinal toxicity in various species. Toxicol Pathol. 16(2):245-50.